Enter: argireline. The active is often referred to as “Botox in a bottle” thanks to its ability to inhibit muscle movement in almost the same way as the real deal – no needles required. Plus, it boosts collagen, making your skin look smoother and firmer overall.
To be clear, this is not Botox, so you’ll want to level your expectations accordingly. But if you’re looking for an accessible alternative that you can buy for as little as $10, no needles required, this might just be for you.
What is Argireline?
“Argireline – which is written in ingredient lists as acetyl hexapeptide-3 or acetyl hexapeptide-8 – is a peptide that works by preventing the release of neurotransmitters to activate muscle movement, producing a Botox-like effect,” says Jodi LoGerfo, DNP, aesthetic nurse practitioner. “Argireline has also been shown to help encourage collagen production, possibly increasing skin tone and firmness. Studies show it can improve the appearance of fine lines and wrinkles, especially on the forehead. and around the eyes.
And how does he do that? “Argireline acts on the neuromuscular junction like Botox, but with a different form of action and revealing a different result”, explains Rebecca Marcus, MD, FAADboard-certified dermatologist and skincare brand founder Maei MD. According to a 2021 study that called silver line “a safe, needle-free alternative to Botox”, the ingredient works by “inhibiting the release of neurotransmitters in the neuromuscular junction, producing a botox-like effect”.
In simpler terms, this means that Argireline penetrates the deeper layers of the skin and targets neurotransmitters (i.e. brain chemicals) that stimulate muscle movement. This prevents the muscles from contracting, which prevents them from causing wrinkles, leaving the skin smooth and firm.
How does argireline compare to Botox?
“The effects of Argirilene are temporary and much less dramatic than those of Botox,” says Dr. Marcus.
While Botox can completely erase wrinkles and last for months, Argireline must be used more regularly to see comparable effects. According research 2018, a twice-daily application of the ingredient reduced wrinkles by up to 48% in four weeks. “Compared to Botox, the effects of argireline are much more subtle,” says Dr. Marcus. “Also, Argireline produces a very temporary effect, whereas the effects of Botox can last around three months.”
Divya Shokeen, MDboard-certified medical, surgical and cosmetic dermatologist and founder of Ocean Skin and Veins Instituteadds that argireline is especially helpful for those who aren’t yet ready for more invasive treatments like Botox but still want to see similar, albeit temporary, effects.
“Although argireline and Botox work by targeting the facial muscles responsible for wrinkles, they are not interchangeable,” she says. “Botox is a prescription drug that is injected into the muscles and paralyzes them, while argireline is a topical cosmetic ingredient that relaxes the muscles. Botox is generally more effective than argireline, but it has more potential side effects and requires a healthcare professional to administer it.”
If you’re looking for a Botox-like effect that doesn’t require a trip to the dermatologist, Argireline is the ingredient to try.
buy argireline for skin
Dr. Dennis Gross, DermInfusions™ Fill + Repair Serum — $75.00
Clinically proven to improve the appearance of fine lines, this offering from Dr. Dennis Gross is a plumping and firming masterpiece. It contains argireline, four weights of hyaluronic acid, four different peptides, niacinamide and ectoin to rejuvenate the skin and act as a filler, in that it visibly fills in wrinkles and gives skin looks plumper, fresher and plumper. Have been sold.
Estée Lauder, Revitalizing Supreme+ Youth Power Moisturizer — $98.00
Estée Lauder’s Revitalizing Supreme+ Youth Power Moisturizer is so beloved that it has just under 3,000 reviews on Sephora at the time of writing, and we can see why. Its ingredient list includes cactus stem cell extract and hyaluronic acid to soak skin in up to 72 hours of hydration, and hibiscus morning bloom extract provides lifting and firming properties. . All these powerful active ingredients are combined in a soft formula with a luxurious texture that smells good.
Paula’s Choice, Calm Rescue and Repair Lightweight Moisturizer — $33.00
Your new summer moisturizer has arrived! The feather-light formula keeps skin hydrated and nourished for up to 24 hours, with argireline, mushroom extract and squalane which work to reduce redness, fine lines and help maintain the skin barrier in good health. A great option for sensitive, oily and combination skin, it leaves skin feeling plump without clogging pores or causing irritation.
Peter Thomas Roth, Super-Size Anti-Wrinkle Eye Concentrate – $200.00
This is no ordinary eye cream. It contains no less than six neuropeptides (including argireline), plus matrixyl 3000, a double peptide, to reduce fine lines and wrinkles. and crow’s feet. After four weeks of use, 91% of testers agreed their under-eye area felt soft and smooth, and 86% said their skin felt tighter and tighter. It is also suitable for people with sensitive skin around the eyes and those who wear contact lenses.
La Mer, The Revitalizing Moisturizing Serum — $255.00
Although on the expensive end of the spectrum, Revitalizing Moisturizing Serum is an air-light formula infused with micro-droplets of green, brown and red algae, which is designed to quickly and effectively absorb into the skin’s surface, as well as as antioxidants to prevent the skin from free radicals and, of course, argireline to target fine lines and wrinkles. Simply apply one to two drops to your face morning and night.
The Ordinary Solution, Argireline 10% – $9.00
The Ordinary is renowned for affordable formulas that actually work, and their argireline-infused solution is no exception, so much so that it often sells out because fans call it “botox in a bottle.” Apply to forehead and around eyes morning and night to see results, such as smoother skin, diminished fine lines, and a brighter, firmer complexion.
111SKIN, Celestial Black Diamond Eye Cream — $300.00
In addition to argireline, 111SKIN’s Celestial Black Diamond Eye Cream contains an impressive cocktail of ingredients, including centella asiatica to stimulate collagen production and plump up fine lines, arbutin to improve pigmentation and fine diamond powder to ensure the absorption of ingredients by fine skin. under the eye. Yes please.
Medik8, 30% Liquid Peptide Complex Hydrating Peptide Serum — $62.00
For the price, this serum really packs a punch in terms of ingredients. It contains a blend of peptides (including Argireline) to wrap your skin in plumping and nourishing benefits. It also uses a Matrixyl 3000 complex to further reduce the appearance of fine lines and wrinkles, as well as hyaluronic acid for its moisturizing properties. Prime? It’s also vegan, cruelty-free, and alcohol-free.
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